Issa SAMB
University Alioune Diop of Bambey, Senega
Title: Pyrimidino-pyranoside: A scaffold for drug discovery
Biography
Biography: Issa SAMB
Abstract
The use of carbohydratebased scaffolds for the construction of biologically active compounds is now a well-accepted concept. Our work consists of constructing a bicyclic glucosidic scaffold and studying its potential functionalization for the peptidomimetic design. Starting from methyl α-Dmannopyranoside, we describe rapid access to chiral bicyclic sugar scaffold and its functionalization via Palladiocatalyzed reactions (Suzuki and Stille). The cleavage of benzylidene acetal was carried out by acidic hydrolysis and different alkylation methods with alkyl halides were investigated. This work will provide rapid access to small libraries of new analogs of peptidic receptor ligands (RGD) implied in pathology like cancer and thrombosis.